Part of the Boxcar Comics collective, 21 Dead Monkeys is credited to the pseudonymous “mmr21” and takes a Penny Arcade like approach to indy music culture (I’m using indy in the broadest sense to mean non- or at least non-big-corporate). Every update is a webcomic and a rant with lots of references to bands, tours and the latest sell-out outrage. There’s definitely a level to the webcomic you won’t get if you’re not familar with the bands and music discussed, but on the other hand there are some jokes that work even if you’re idea of indy music is Madonna unplugged. And even though there’s not much story, there are recurring characters that have developed personalities over time.
A lot of webcomics focused on music seem to have a “we’re not worthy” relationship to genre pioneer Mitch Clem, but really 21 Dead Monkeys stands on its own as a smart and knowledgeable webcomic.